The STEPUPIORS participated in the 13th Congress of the Serbian Society of Toxicology with international participation and the 1st TOXSEE Regional Conference

The STEPUPIORS team participated in the 13th Congress of the Serbian Society of Toxicology with international participation and the 1st TOXSEE Regional Conference entitled “Present and Future of toxicology: challenges and opportunities“, which were held from May 10 to 12, 2023 in Belgrade. Dr. Ana Đurić presented the joint work of members of the STEPUPIORS Twinning project entitled “Is there a relation between hematological toxicity and response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer?” whose objective was to evaluate the association between hematologic toxicity and tumor response to therapy. The research included 75 patients, who were treated at the Institute of Oncology and Radiology of Serbia in the period from June 2020 to January 2022. By further targeted monitoring of defined hematological parameters, the study will provide answers that contribute to the progress of a personalized approach to the treatment of patients with this malignancy disease.

During the three days of the congress, participants had the opportunity to listen to lectures by colleagues from Serbia and abroad, which covered a wide range of important topics in the field of contemporary toxicology. It was an honor and pleasure for us to share our results with our colleagues, as well as to participate in a meeting of exceptional educational and scientific importance for our community.



ELISA training at IORS

Dr Ana Vuletić and Dr Katarina Mirjačić Martinović organized a basic two-day course related to ELISA method for IORS project participants and other interested IORS colleagues.

During the first day, theoretical principles of ELISA method were presented, while the second day was dedicated to a practical step-by-step approach how sandwich ELISA works. As a practical exercise the level of IL-10 in the sera was analyzed.

Thanks to the excellent organization of the course, all attendees were thoroughly trained to construct a standard curve and determine the concentration of IL-10 in serum samples. The participants of the course, Aleksandra Stanojević, Kristina Živić, Katarina Živić, Miodrag Vuković, Maja Petrović, and Dušica Petrović are now ready to successfully perform the ELISA method independently.



Strategic 6-month project meeting at IORS

A strategic meeting of STEPUPIORS project participants, IORS Director Dr Milan Zegarac, Deputy Director Dr Dejan Stojiljkovic and Heads of administrative departments was held on April 05, 2023, to review project achievements in the first 6 months. Project Coordinator Dr Milena Cavic presented all performed activities, encompassing a successful kickoff meeting coupled with a pre-award training, presentations at congresses, outreach promotions, expert visits, training and scientific results.

It was concluded that the project start has been very active and successful, with 5 deliverables and 1 milestone already submitted to the European Research Executive Agency. Strategies for further project development were previously set in place with partner institutions. Project participants expressed enthusiasm for the continuance of all activities. IORS Management strongly supported future plans for enhancing personnel, scientific and communication capacities of the Institute for Oncology and Radiology of Serbia.



Collaboration with EPIBOOST Horizon Europe Twinning Project

On April 5, 2023, a Twinning focus group was initiated by the Horizon Europe EPIBOOST project from the University of Aveiro, Portugal, with active contribution of STEPUPIORS Coordinator Dr Milena Cavic. Identifying the need to complement current official guidelines, the collaborative group aims to produce detailed real-world-experience based project management guidelines for future successful Twinning project applicants, by collecting data from multiple countries and institutions.



Establishment of a Research Management Team at IORS (D5.2)

After intensive six-month practices at partner institutions’ project management offices and external trainings, a Decision to form a Research Management Team at IORS was issued on March 08, 2023, that would serve as a prototype for the future IORS Research Management Office. The Team consists of project Management staff Dr Milena Čavić, Dr Ana Đurić and Dr Marko Radulović, the Head of IORS Scientific Department Dr Radmila Janković, Heads of IORS Procurement, Legal and Financial Departments and representatives of laboratory technical staff. The Team will liaise project activities between the IORS research team and the local legal, administrative, procurement and human resources IORS staff to enable a more effective project flow. The Team will also perform risk mitigation continuously during the project and strive to coordinate future intellectual property applications at the national and international level.

D5.2 STEPUPIORS



Colorectal Cancer Awareness Activities in Belgrade

STEPUPIORS researchers participated in various scientific and outreach project activities in March and April 2023 to raise awareness about colorectal cancer.  Through interesting practical sessions, Dr Ana Đurić and Dr Milena Čavić communicated the  principles of digestion and the importance of a healthy lifestyle from a young age in the fight against colorectal cancer to pre-school children. Dr Suzana Stojanovic-Rundic, Dr Jelena Spasic, Dr Radmila Jankovic and Dr Mladen Marinković participated as invited lecturers at the First School for malignant tumors of the digestive tract organized by the Society of Medical Oncologists of Serbia on March 31/April 01, 2023. Dr Radmila Janković gave an interview on the importance of precision medicine in oncology for the RadioTelevison Serbia Science Portal on April 02, 2023. The team also contributed steps to support Digestive Cancers Europe’s initiative “Step Up for CRC”, focused on increasing awareness that colorectal cancer risk can be reduced by regular physical activity.



Research into germline DNA alterations that predispose to colorectal cancer

The Gastrointestinal and Pancreatic Oncology Team of STEPUPIORS PI Dr Sergi Castellví-Bel from the Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS) and Hospital Clínic de Barcelona aims at deciphering alterations in germline DNA that predispose to colorectal cancer.



March 13-14, 2023, "How to build a biobank" Training at Medical University Graz, Austria

STEPUPIORS participants attended a productive biobanking training with interesting networking at Medizinische Universität Graz in the beautiful city of Graz, Austria, in the period March 13-14, 2023.
Along with great efforts and a lot of precious knowledge that was previously poured into the future IORS biobanking staff by partner institutions, STEPUPIORS biobanking will officially start on April 01, 2023.



Lecture at "Next Generation Scientists" meeting in Belgrade, Serbia

STEPUPIORS project participants Dr Marija Đorđić Crnogorac and Katarina Živić participated at the “Next Generation Scientists” meeting in Belgrade, Serbia on March 09, 2023. Dr Đorđić Crnogorac gave a lecture on genetic testing of hereditary cancers including Lynch syndrome using NGS methodology at the Institute for Oncology and Radiology of Serbia. The process and criteria for Lynch syndrome testing were presented as well as results from the period 2018-2023.



Outreach event in collaboration with Researcher's Night project ScienceSCool

Members of the STEPUPIORS team, Dr Ana Đurić and Aleksandra Stanojević, had the honor and pleasure to discuss with students of the Gymnasium Svetozar Marković in Subotica, through an interactive presentation, how healthy lifestyle habits play a crucial role in the prevention of colorectal cancer. The significance of stronger involvement of young students in scientific research was also highlighted in an effort to engage young generations in the advancement of science in Serbia.
The event was organized by European Researcher’s Night project Science on the move – from lab to streets & school (ScienceSCool – 101061631).