STEPUPIORS Annual Project Meeting

The annual project meeting successfully gathered project participants from all 4 collaborating countries. Within the annual meeting period, a Post-award Grant Management Training was held for 68 Serbian future grant holders and leaders from 11 institutions. Round table discussions and sharing experience of several principal investigators of successful EU-funded and national grants from Serbia concluded the training.

After the Training, first project deliverables and milestones were outlined:

1 Biobank successfully established at IORS
4 Publications and multiple congress abstracts presented
3 large trainings on grant management and omics approaches
Many interesting outreach activities
1 Research Management Office successfully established at IORS

The event was dynamic and joyful, stimulating new collaborations and project applications. We look forward to project year 2 – the best is yet to come!



STEPUPIORS at SDIR-6 Congress of the Serbian Association for Cancer Research

STEPUPIORS members participated at the European Association for Cancer Research (EACR)-supported Sixth Congress of the Serbian Association for Cancer Research (SDIR) “From Collaboration to Innovation in Cancer Research” held in Belgrade on October 02-04, 2023 as Invited Speakers (Snežana Bjelogrlić, Katarina Mirjačić Martinović, Jelena Spasic), Session Chairs (Radmila Jankovic, Miljana Tanic, Jelena Spasic, Ana Krivokuca, Milena Cavic, Remond Fijneman, Ieronymos Zoidakis, Marko Radulovic, Sergi Castellvi-Bel), Meet the Experts hosts (Remond Fijneman, Ieronymos Zoidakis), Oral Presenters (Mladen Marinkovic), Poster Presenters (Aleksandra Stanojevic, Kristina Zivic, Katarina Zivic) and members of the Scientific and Organizing Committee (Ana Djuric, Ana Damjanovic, Marija Djordjic Crnogorac, Valentina Karadzic, Ana Vuletic).

Dr Snežana Bjelogrlić presented a lecture “Establishment of a first cancer Biobank at the Institute for Oncology and Radiology of Serbia – advantages, challenges and future perspectives”

Dr Mladen Marinkovic presented an oral abstract “Predicting response to chemoradiotherapy in locally advanced rectal cancer using MRI-based radiomics features”

Aleksandra Stanojević presented a poster “Detection of viral proteins in locally advanced rectal cancer patient samples by mass spectrometry – predictive potential for response to neoadjuvant chemoradiotherapy” and won the Best PhD Student Abstract Award!

The three-day conference was held at a high-step pace with excellent exchange of latest cancer research achievements in the region and Europe.



STEPUPIORS team at the European Researchers` Night

Dear researchers and citizens,

Let’s make sure our beautiful science is easily understandable to everyone!

After playing fun scientific games with an enthusiastic 0-99 audience on September 30, 2023 during the European Researchers Nights, we are sure that only the sky is the limit for the future development of science in Serbia!



September 2023 Project Activities

Dr Ana Damjanovic and Dr Milena Cavic participated in a Radio program “Hocu da znam” at Radio Beograd 2 hosted by the multi-talented Tomica Mišljenović. They discussed the project aims and planning of a satellite training symposium/annual meeting during the SDIR-6 Congress of the Serbian Association for Cancer Research (recording in Serbian).

Dr Katarina Mirjačić Martinović attended the ESMO Preceptorship on Immuno-Oncology in Zurich organized by the European Society for Medical Oncology.

Dr Milena Cavic attended the Focus group on Twinning project management during the EPIBOOST project annual meeting. The establishment and progress of the good Twinning practices guide were discussed and plans for the next two years set in place.



Title: Published preprint to celebrate the World Cancer Research Day

In celebration of #WorldCancerResearchDay – a new collaborative manuscript was posted online:
Stanojevic A, Spasic J, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Djuric A, Zoidakis J, Fijneman R, Castellvi-Bel S, Cavic M. Methylenetetrahydrofolate reductase polymorphic variants in rectal cancer: significance for cancer risk and response to chemoradiotherapy. medRxiv 2023.09.21.23295916; doi: https://doi.org/10.1101/2023.09.21.23295916



Dr Milena Cavic lecturer at the European Training Academy's Horizon Europe Twinning projects writing training

STEPUPIORS PI Dr Milena Cavic participated as a lecturer at a training for writing Horizon Europe Twinning projects for participants from 12 scientific institutions from Serbia and Bosnia and Herzegovina, organized by the European Training Academy in Belgrade, on September 04, 2023, in a hybrid mode. Participants received instructions from experienced trainers on how to write a project proposal and how to prepare a budget according to the new Lump Sum methodology. Finally, they had the opportunity to meet other funded Twinning project coordinators, representing GrInShield Twinning Project from the Vinca Institute of Nuclear Sciences, TwiNSol – CECs from the Faculty of Technology Novi Sad, University of Novi Sad, BIOLAWEB from the Institute for Chemistry, Technology and Metallurgy.

Dr Cavic presented project aims, evolution, current status and implementation challenges followed by a lively discussion. The meeting was very useful for future Twinning coordinators, giving an excellent example on how to expand the network of Serbian successful project applications. It was also useful for meeting other Twinning project coordinators which facilitated new collaborations between STEPUPIORS and other Serbian Twinning projects starting from October 2023.



New Scientific Publication within WP2

A collaborative article depicting novel genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer was published in Frontiers in Genetics.
Marinkovic M, Stojanovic-Rundic S, Stanojevic A, Ostojic M, Gavrilovic D, Jankovic R, Maksimovic N, Stroggilos R, Zoidakis J, Castellví-Bel S, Fijneman RJA, and Cavic M. Exploring novel genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Front. Genet. 2023, 14:1245594. doi: 10.3389/fgene.2023.1245594. link: https://www.frontiersin.org/articles/10.3389/fgene.2023.1245594/full

The standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy. To select patients who would benefit the most from this treatment, there is a need for predictive biomarkers. The aim of this study was to evaluate the role of clinical, pathological, radiological, inflammation-related genetic, and hematological parameters in the prediction of post-nCRT response. The obtained results showed that factors associated with favorable response to neoadjuvant chemoradiotherapy were tumor morphology and hematological parameters which can be easily and routinely derived from initial laboratory results (NMR, eosinophil, basophil and monocyte counts) in a minimally invasive manner. Using various metrics, an aggregated score of the initial eosinophil, basophil, and monocyte counts demonstrated the best predictive performance.

Congratulations to the first author Mladen Marinkovic, MD, for a great achievement and a wonderful rest of his PhD journey ahead!



Dr Milena Cavic and Prof. Makis Zoidakis lecturers at 5ISSCBSD

STEPUPIORS PIs Dr Milena Cavic and Prof. Makis Zoidakis participated as lecturers at the 5th International Summer School on  Circular Bio-economy and Sustainable Development organized by the National and Kapodistrian University of Athens, in Thessaloniki, Greece, and online.
Dr Cavic presented project aims through implementing principles of circular bio-economy and sustainable development in the establishment of a first cancer Biobank and Research Management Office at the Institute for Oncology and Radiology of Serbia, while Prof Zoidakis presented information concerning the contribution of proteomics to sustainable development.
The summer school was very useful for familiarization with current trends in bioeconomy, with Increased interest particularly in the Balkan region. New aspects and perspectives in sustainability and development were delivered highlighting  hands-on student involvement. Vivid discussions led to new ideas and collaborative approaches for future grant applications aimed at sustainable scientific research.



STEPUPIORS Outreach events in kindergartens

Our first project year was filled with many important and inspiring events. Of particular importance was our work with young people and children on their education about healthy food and a healthy lifestyle. In addition to visiting elementary schools, we also visited children from two kindergartens in Belgrade, PU “Poletarac” from Palilula and PU “Lunja” from Vračar. Dr Ana Đurić, Dr Milena Cavic and Dr Marija Đorđić Crnogorac, in a good atmosphere through games and fun, encouraged children to think about healthy lifestyle habits that are extremely important for their future and proper psychophysical development. How the children accepted these topics and how willing they were to learn new knowledge is best described by their numerous drawings that we received as a gift.

The STEPUPIORS team invites you to selflessly continue to spread your knowledge about all that is good, especially among those who are most important to us and who will come after us. Our children’s knowledge and skills are changing the world for the better, and we are honored to be able to contribute in our own way.