September 2023 Project Activities

Dr Ana Damjanovic and Dr Milena Cavic participated in a Radio program “Hocu da znam” at Radio Beograd 2 hosted by the multi-talented Tomica Mišljenović. They discussed the project aims and planning of a satellite training symposium/annual meeting during the SDIR-6 Congress of the Serbian Association for Cancer Research (recording in Serbian).

Dr Katarina Mirjačić Martinović attended the ESMO Preceptorship on Immuno-Oncology in Zurich organized by the European Society for Medical Oncology.

Dr Milena Cavic attended the Focus group on Twinning project management during the EPIBOOST project annual meeting. The establishment and progress of the good Twinning practices guide were discussed and plans for the next two years set in place.



Title: Published preprint to celebrate the World Cancer Research Day

In celebration of #WorldCancerResearchDay – a new collaborative manuscript was posted online:
Stanojevic A, Spasic J, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Djuric A, Zoidakis J, Fijneman R, Castellvi-Bel S, Cavic M. Methylenetetrahydrofolate reductase polymorphic variants in rectal cancer: significance for cancer risk and response to chemoradiotherapy. medRxiv 2023.09.21.23295916; doi: https://doi.org/10.1101/2023.09.21.23295916



Dr Milena Cavic lecturer at the European Training Academy's Horizon Europe Twinning projects writing training

STEPUPIORS PI Dr Milena Cavic participated as a lecturer at a training for writing Horizon Europe Twinning projects for participants from 12 scientific institutions from Serbia and Bosnia and Herzegovina, organized by the European Training Academy in Belgrade, on September 04, 2023, in a hybrid mode. Participants received instructions from experienced trainers on how to write a project proposal and how to prepare a budget according to the new Lump Sum methodology. Finally, they had the opportunity to meet other funded Twinning project coordinators, representing GrInShield Twinning Project from the Vinca Institute of Nuclear Sciences, TwiNSol – CECs from the Faculty of Technology Novi Sad, University of Novi Sad, BIOLAWEB from the Institute for Chemistry, Technology and Metallurgy.

Dr Cavic presented project aims, evolution, current status and implementation challenges followed by a lively discussion. The meeting was very useful for future Twinning coordinators, giving an excellent example on how to expand the network of Serbian successful project applications. It was also useful for meeting other Twinning project coordinators which facilitated new collaborations between STEPUPIORS and other Serbian Twinning projects starting from October 2023.



New Scientific Publication within WP2

A collaborative article depicting novel genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer was published in Frontiers in Genetics.
Marinkovic M, Stojanovic-Rundic S, Stanojevic A, Ostojic M, Gavrilovic D, Jankovic R, Maksimovic N, Stroggilos R, Zoidakis J, Castellví-Bel S, Fijneman RJA, and Cavic M. Exploring novel genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Front. Genet. 2023, 14:1245594. doi: 10.3389/fgene.2023.1245594. link: https://www.frontiersin.org/articles/10.3389/fgene.2023.1245594/full

The standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy. To select patients who would benefit the most from this treatment, there is a need for predictive biomarkers. The aim of this study was to evaluate the role of clinical, pathological, radiological, inflammation-related genetic, and hematological parameters in the prediction of post-nCRT response. The obtained results showed that factors associated with favorable response to neoadjuvant chemoradiotherapy were tumor morphology and hematological parameters which can be easily and routinely derived from initial laboratory results (NMR, eosinophil, basophil and monocyte counts) in a minimally invasive manner. Using various metrics, an aggregated score of the initial eosinophil, basophil, and monocyte counts demonstrated the best predictive performance.

Congratulations to the first author Mladen Marinkovic, MD, for a great achievement and a wonderful rest of his PhD journey ahead!



Dr Milena Cavic and Prof. Makis Zoidakis lecturers at 5ISSCBSD

STEPUPIORS PIs Dr Milena Cavic and Prof. Makis Zoidakis participated as lecturers at the 5th International Summer School on  Circular Bio-economy and Sustainable Development organized by the National and Kapodistrian University of Athens, in Thessaloniki, Greece, and online.
Dr Cavic presented project aims through implementing principles of circular bio-economy and sustainable development in the establishment of a first cancer Biobank and Research Management Office at the Institute for Oncology and Radiology of Serbia, while Prof Zoidakis presented information concerning the contribution of proteomics to sustainable development.
The summer school was very useful for familiarization with current trends in bioeconomy, with Increased interest particularly in the Balkan region. New aspects and perspectives in sustainability and development were delivered highlighting  hands-on student involvement. Vivid discussions led to new ideas and collaborative approaches for future grant applications aimed at sustainable scientific research.



STEPUPIORS Outreach events in kindergartens

Our first project year was filled with many important and inspiring events. Of particular importance was our work with young people and children on their education about healthy food and a healthy lifestyle. In addition to visiting elementary schools, we also visited children from two kindergartens in Belgrade, PU “Poletarac” from Palilula and PU “Lunja” from Vračar. Dr Ana Đurić, Dr Milena Cavic and Dr Marija Đorđić Crnogorac, in a good atmosphere through games and fun, encouraged children to think about healthy lifestyle habits that are extremely important for their future and proper psychophysical development. How the children accepted these topics and how willing they were to learn new knowledge is best described by their numerous drawings that we received as a gift.

The STEPUPIORS team invites you to selflessly continue to spread your knowledge about all that is good, especially among those who are most important to us and who will come after us. Our children’s knowledge and skills are changing the world for the better, and we are honored to be able to contribute in our own way.



Participation at EACR23 Congress, June 12-15, 2023, Torino, Italy

Project members Ana Đurić and Aleksandra Stanojević present project results within WP1 and WP2 at the European Association for Cancer Research (EACR) EACR 2023 Congress held on June 12-15, 2023 in Torino Italy.
Dr Đurić and Ms Stanojević presented two posters and discussed with congress participants on future collaboration prospects.

* P-0466 The Road from Human Sample Collections to the First Rectal Cancer Biobank at the Institute for Oncology and Radiology of Serbia (Ana Đurić et al.)

* P-0083 Correlation between genetic and proteomic expression of predictive biomarkers of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer identified by data independent acquisition mass spectrometry (Aleksandra Stanojević et al.)



© 2023 STEPUPIORS. All rights reserved

Project ID:  101079217 (HORIZON-WIDERA-2021-ACCESS-03)

Funded by the European Union. Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the European Research Executive Agency can be held responsible for them

Project ID:  101079217 (HORIZON-WIDERA-2021-ACCESS-03)

Funded by the European Union. Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the European Research Executive Agency can be held responsible for them

© 2023 STEPUPIORS. All rights reserved

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